Keywords: cholecalciferol, childhood overweight, hypovitaminosis DĬhildhood obesity is a major global health crisis. More research is needed to define optimal vitamin D status in this vulnerable population, including investigations to determine the efficacy of vitamin D supplementation in attenuating the conditions associated with childhood obesity, and to further elucidate the mechanisms by which vitamin D exerts its effects on health. Weight loss interventions using energy restriction and physical activity may also improve the poor vitamin D status associated with obesity. Therefore, in obese children, vitamin D supplementation is warranted. Likewise, obtaining adequate vitamin D from natural food sources alone is generally not achievable, and even in countries that allow fortification, vitamin D intakes are low.
#World of goo nds skin
Although ultraviolet B-induced skin synthesis is a main source of vitamin D, its use is neither feasible nor prudent due to limited sun availability for many and concerns for skin cancer. Most of the findings to date suggest that the vitamin D needs of obese children are greater than the nonobese. The rather ubiquitous distribution of the vitamin D receptor and the 25-hydroxyvitamin D 1a-hydroxylase throughout the body, including evidence for a role of vitamin D in adipogenesis and adipocyte metabolism, may in part explain these widespread effects. The effects of this deficiency in childhood obesity appear to have negative influences on overall health, including insulin resistance, inflammation, and impeded bone mineralization, as well as increased future risk of type 2 diabetes, cardiovascular disease, and osteoporosis. It is not clear whether vitamin D deficiency contributes to, or is a consequence of obesity, or whether there are regulatory interactions between excess adiposity and vitamin D activity. Observational and clinical studies show that vitamin D status and fat mass are inversely correlated. I could go on, but just trust me when I say you should start collecting some goo for yourself.Department of Nutrition and Exercise Physiology, University of Missouri-Columbia, Columbia, MO, USAĪbstract: Vitamin D deficiency and childhood obesity have been classified as epidemics throughout the world, and both share some common risk factors including poor diet and inactivity. Visually, the game itself feels like a juxtaposition of a nostalgic past through the lens of Saturday morning cartoons with hallucinatory, hypnotic visions of the future. Sure, the box which the game comes in looks a little bit plain. The design is breathtaking, the levels of interaction are countless, there is great sync between the controller and the on-screen action and the visuals vibrate with amazing color and depth. At its core, World of Goo is a puzzle game, but it is really so much more than that. I know I must sound insane, but you need to play this game for yourself. It’s that good.Īll of the myriad different things to do in this game are almost overwhelming seemingly mundane tasks such as moving goo, creating goo and solving goo-related puzzles take on importance that cannot be properly quantized with words from the English language.
This sounds ridiculous, but the game combines a story line that is very affecting by any standard, graphics that leave players stunned and amazed and a level of game play rivaled by no other game currently on the market.
There is so much to say about this fantastic title.ĭeveloped by 2D Boy (a pair of guys from San Francisco who have collectively worked for Maxim, EA and ), the basic premise of the game is to move goo. My favorite independent video game to be recently released is World of Goo.
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